A STUDY OF LIVE INFLUENZA VIRUS VACCINE IN PATIENTS WITH CHRONIC BRONCHITIS

A STUDY OF LIVE INFLUENZA VIRUS VACCINE IN PATIENTS WITH CHRONIC BRONCHITIS

A STUDY OF LIVE INFLUENZA VIRUS VACCINE IN PATIENTS WITH CHRONIC BRONCHITIS

Abstract

A multicentre study of the effects of influenza virus RIT 4050 (H3N2) in patients with
chronic bronchitis was conducted by members of an MRC Committee. The results
showed that RIT 4050 vaccine virus did not cause a deterioration in clinical or physiological
status in these patients within the limitation of the relatively reproducible ventilatory
tests which were employed. This conclusion applied equally to those who were
inoculated and became infected and to those who failed to develop serological evidence
of infection. The relatively high proportion of antibody-negative volunteers not infected
by the inoculated virus raises doubts concerning the value of this method of immunization
for patients at risk during influenza epidemics.

read online

 

Post Comment