Biochemical biomarkers in Alzheimer's disease-Original PDF

Biochemical biomarkers in Alzheimer’s disease-Original PDF

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By Samuel Barrack(Author)

Size : 10.84 MB

In view of the growing prevalence of AD worldwide, there is an urgent need for the development of better diagnostic tools and more effective therapeutic interventions. Indeed, much work in this field has been done during last decades. As such, a major goal of current clinical research in AD is to improve early detection of disease and presymptomatic detection of
neuronal dysfunction, concurrently with the development of better tools
to assess disease progression in this group of disorders. All these putative
correlates are commonly referred to as AD-related biomarkers. The ideal
biomarker should be easy to quantify and measure, reproducible, not
subject to wide variation in the general population and unaffected by comorbid
factors. For evaluation of therapies, a biomarker needs to change
linearly with disease progression and closely correlate with established
clinico-pathological parameters of the disease.
There is growing evidence that the use of biomarkers will increase our
ability to better indentify the underlying biology of AD, especially in its early
stages. These biomarkers will improve the detection of the patients suitable
for research studies and drug trials, and they will contribute to a better
management of the disease in the clinical practice. Indeed, much work in
this field has been done during last decades. The vast number of important
applications, combined with the untamed diversity of already identified
biomarkers, show that there is a pressing need to structure the research
made on AD biomarkers into a solid, comprehensive and easy to use tool to
de deployed in clinical settings.
To date there are few publications compiling results on this topic. That is why
when I was asked to address this task I accepted inmediately. I am happy
to present you a bundle of the best articles published about biomarkers for
Alzheimer’s disease in recent times.

Product details

  • Paperback: 148 pages
  • Publisher: CreateSpace Independent Publishing Platform (October 20, 2013)
  • Language: English
  • ISBN-10: 1492274461
  • ISBN-13: 978-1492274469