Respiratory Disease Series: Diagnostic Tools and Disease Managements
Series Editors
Hiroyuki�Nakamura
Ibaraki Medical Center, Tokyo Medical University, Ibaraki, Japan
Kazutetsu�Aoshiba
Ibaraki Medical Center, Tokyo Medical University, Ibaraki, Japan

This book series cover a variety of topics in respiratory diseases, with each volume providing an overview of the current state of knowledge, recent discoveries and future prospects for each disease. In each chapter the editors pose critical questions, which are often unresolved clinical issues. These are then discussed by the authors, providing insights and suggestions as to which developments need to be addressed. The series offers new information, which will inspire innovative ideas to further develop respiratory medicine.This collection of monographs is aimed at benefiting patients across the globe suffering from respiratory disease.

Edited by established authorities in the field and written by pioneering experts, this book series will be valuable to those researchers and physicians working in respiratory medicine. The series is aimed at a broad readership, and the books will also be a valuable resource for radiologists, emergency medicine physicians, pathologists, pharm

More information about this series at http://?www.?springer.?com/?series/?15152 acologists and basic research scientists.

Editors
Takashi�Nakano and Takashi�Kijima

Malignant Pleural Mesothelioma

Advances in Pathogenesis, Diagnosis, and Treatments

1st ed. 2021
Editors
Takashi�Nakano
Center Respiratory Medicine, Otemae Hospital, Osaka, Japan
Takashi�Kijima
Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
ISSN 2509-5552e-ISSN 2509-5560
Respiratory Disease Series: Diagnostic Tools and Disease Managements
ISBN 978-981-15-9157-0e-ISBN 978-981-15-9158-7
� Springer Nature Singapore Pte Ltd. 2021
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Preface

Mesothelioma is an infrequent, aggressive malignant tumor that develops in the mesothelial cell layer of the pleural and peritoneal cavities, as well as the pericardium and the tunica vaginalis testis. Its global incidence has steadily risen along with widespread exposure of individuals to asbestos throughout the twentieth century. Those who have a history of asbestos exposure perceive worries about being high-risk group of developing fatal mesothelioma in future. Exposure to asbestos is a well-known cause of mesothelioma; however, there are many difficulties in understanding mesothelial cell carcinogenesis seen in patients exposed to no known or quite low-dose environmental exposure. A small number of mesothelioma patients with familial aggregation are associated with constitutional germ line BAP1 mutation, who also develop other tumors such as melanoma and clear cell renal carcinoma. Recent marked progress in basic and clinical researches on this neoplasm elucidates some crucial evidence relating to molecular pathogenesis and perspectives on potential therapeutic approaches leading to promising treatment.

This book is designed to provide a state-of-the-art overview of the most recent scientific researches on mesothelioma, encompassing epidemiology, pathology, genetics, carcinogenesis, imaging, and treatment, together into a single publication. Mesothelioma is a complex scientific tumor and remains a public health issue; therefore, this book also has a significant impact on medicolegal aspects of this disease. All the authors are world-renowned experts in their field and present updates of their research on mesothelioma. We hope that the contents of this book will encourage the readers not only to learn more about these topics but to digest the rapid growth of knowledge of scientific mesothelioma research and multidisciplinary treatment approach. This book is aimed to be used by respiratory physicians, pathologists, medical oncologists, radiation oncologists, surgical oncologists, and cancer researchers, as well as by residents and fellows in training.

We, chapter editors, are grateful to all of the authors who took time from their incredibly quite busy schedules, especially in the situation of the SARS-CoV-2 pandemic in 2020, to contribute to this book. Finally, we are indebted to Ms. Chihiro Haraguchi and Ms. Saki Kasai, talented Springer publishing staff, for supporting the editing of this book.

Takashi�Nakano
Takashi�Kijima
Osaka, JapanHyogo, Japan
Contents
Part I?Epidemiology
Diana�Arachi, Matthew�Soeberg, Odgerel�Chimed-Ochir, Ro-Ting�Lin and Ken�Takahashi
Part II?Pathogenesis
Yasumitsu�Nishimura, Naoko�Kumagai-Takei, Suni�Lee, Kei�Yoshitome, Tatsuo�Ito and Takemi�Otsuki
Giovanni�Gaudino, Michael�Minaai, Michele�Carbone and Haining�Yang