Contents

Introduction to the Fifth Edition and Historical Highlights

Jacob V. Aranda and JOHANNES N. VAN DEN ANKER

SECTION I: General Principles

1. Clinical Trials Involving Children: History, Rationale, Regulatory Framework, and Technical Considerations

Steven Hirschfeld, Susan McCune, Lynne Yao, Donna L. Snyder, Gerri R. Baer, Bridgette L. Jones, AND Anne Zajicek

2. Clinical Pharmacokinetics in Infants and Children

Edmund V. Capparelli

3. Developmental Pharmacodynamics, Receptor Function, and Drug Action in Newborns and Children

Hussain Mulla

4. Drug Absorption, Distribution, Metabolism, Excretion, and Transporters in Newborns and Children

Stephani L. Stancil, Alenka Chapron, AND Susan M. Abdel-Rahman

5. Pharmacogenetics, Pharmacogenomics, and Pharmacoproteomics in Newborns and Children

Brian D. Chapron AND J. Steven Leeder

6. Ethics of Drug Research in Newborns and Children

John D. Lantos

7. Precision Medicine and Therapeutic Drug Monitoring

Tomoyuki Mizuno, Philip D. Walson, AND Alexander A. Vinks

8. Drug Formulations for Children

Jörg Breitkreutz

SECTION II: Pharmacology in Special Settings and Population: The Newborn

9. Role of Placenta in Drug Metabolism and Drug Transfer

Jamil M. Kazma, JOHANNES N. VAN DEN ANKER, Karel Allegaert, André Dallmann, AND Homa K. Ahmadzia

10. Maternal Medications During Pregnancy and Lactation

Shinya Ito AND Ruud Verstegen

11. Principles of Neonatal Pharmacology

Karel Allegaert AND JOHANNES N. VAN DEN ANKER

12. Renal Function and Excretion of Drugs in the Newborn

JOHANNES N. VAN DEN ANKER AND Karel Allegaert

13. Neuroprotective Drugs and Perinatal Brain Injury

Floris Groenendaal, Manon Benders, Linda de Vries, AND Frank van Bel

14. Pharmacologic Agents for Neonatal Hyperbilirubinemia

David K. Stevenson, Ronald J. Wong, AND Sota Iwatani

15. Pharmacologic Treatment of Neonatal Apnea

Girija Natarajan, Jose Maria de Andrade Lopes, AND Jacob V. Aranda

SECTION III: Pharmacology in Special Settings and Population

16. Therapeutic Applications in Pediatric Intensive Care

Ashok P. Sarnaik, Zahraa H. Al-Lawati, Tageldin M. Ahmed, AND Mary W. Lieh-Lai

17. Drug Therapy in the Pediatric Emergency Department

Maryann E. Mazer-Amirshahi AND James M. Chamberlain

18. Topical Medications

Victoria Tutag Lehr, Geoffrey A. Potts, AND Mirjana Lulic-Botica

19. Ophthalmologic Drugs in Infants and Children

John D. Roarty

SECTION IV: Antimicrobial Pharmacology

20. Penicillins, Cephalosporins, and Other β-Lactams

Roopali Sharma AND Margaret R. Hammerschlag

21. Glycopeptides, Lipoglycopeptides, and Lipopeptides

Roopali Sharma AND Margaret R. Hammerschlag

22. Aminoglycosides

Karel Allegaert, Anne Smits, AND JOHANNES N. VAN DEN ANKER

23. Macrolides, Clindamycin, and Oxazolidinones

Jennifer Le AND John S. Bradley

24. Fluoroquinolones

Stephan A. Kohlhoff

25. Sulfonamides, Dihydrofolate Reductase Inhibitors, and Dapsone

Nynke G.L. Jager AND David M. Burger

26. Tetracyclines, Chloramphenicol, and Metronidazole

Basim I. Asmar AND Nahed Abdel-Haq

27. Antimalarials

Elizabeth A. Ashley AND Sir Nicholas J. White

28. Anthelminthics Drugs in Children

David J. Diemert

29. Antimycobacterial Drugs (Mycobacterium tuberculosis and Atypical Mycobacteria)

Charles A. Peloquin, Wael A. Alghamdi AND Mohammad H. Al-Shaer

30. Antifungal Agents

Michael J. Smith, William J. Steinbach, Daniel K. Benjamin, Jr., AND Michael Cohen-Wolkowiez

31. Antivirals in Newborns and Children

Claudette L. Poole, David W. Kimberlin, AND Richard J. Whitley

32. Pharmacology of Antiretroviral Drugs in Pregnant and Breastfeeding Women and Their Newborns

Rachel K. Scott, Mark Mirochnick, Brookie M. Best, AND Natella Rakhmanina

SECTION V: Neuropharmacology

33. Anticonvulsants

Victoria Tutag Lehr AND Mitchel T. Williams

34. Antidepressants and Mood Stabilizers

Ayman Saleh, Gabrielle Sky Cardwell, Robert L. Findling, AND Adelaide S. Robb

35. Stimulants, ADHD Treatments, and Antipsychotics

Ekaterina Stepanova, Bradley Grant, Adelaide S. Robb, AND Robert L. Findling

36. Analgesics and Sedatives

Sinno H. P. Simons, Gerbrich E. van den Bosch, AND Dick Tibboel

37. Pharmacologic Management of Neonatal Abstinence Syndrome

Elizabeth Yen, Walter K. Kraft, AND Jonathan M. Davis

38. Local Anesthetic Agents for Regional and Superficial Anesthesia in Infants, Children, and Adolescents

Joseph D. Tobias

SECTION VI: Immunopharmacology, Allergy, and Inflammation

39. Nonsteroidal Anti-Inflammatory Drugs

Sylvain Chemtob, John Jeffrey Reese, Anie Lapointe, Mathieu Nadeau-Vallée, AND Victoria Tutag Lehr

40. Antihistamine Drugs

Diana Muñoz-Mendoza, Kim Jackson, Sasha A. Alvarado, AND Sami L. Bahna

41. Antiasthmatics

Hengameh H. Raissy, Elissa Abrams, H. William Kelly, AND Stanley J. Szefler

42. Immunosuppressive and Immunomodulatory Drugs

Burkhard Tönshoff and Britta Höcker

SECTION VII: Pharmacology of Biologic Drugs

43. Microbial Therapeutics: Beyond Probiotics

Desirée Rivera-Nieves AND Josef Neu

44. Monoclonal Antibodies

Zaid H. Temrikar, Satyendra Suryawanshi, AND Bernd Meibohm

45. Stem Cells

Karen C. Young

46. Drugs, Lung Development, and Pulmonary Surfactant

Alan H. Jobe

47. Childhood Vaccines

Jan Bonhoeffer AND Ulrich Heininger

SECTION VIII: Cardiorenal Drugs

48. Neonatal Cardiovascular Pharmacology

Regan E. Giesinger, A. R. Bischoff, Stephanie M. Boyd, Amy H. Stanford, AND Patrick J. McNamara

49. Antiarrhythmic Drugs: Disorders of Cardiac Rhythm and Pharmacologic Management

Nikola Dragisic, Patrick J. McNamara , Ian H. Law, AND Luis A. Ochoa

50. Antihypertensive Drugs

Thomas G. Wells

51. Diuretics

Jean-Pierre Guignard AND Silvia Iacobelli

SECTION IX: Gastrointestinal Pharmacology

52. Gastrointestinal Drugs

Suruchi Batra AND Laurie S. Conklin

53. Drugs in Inflammatory Bowel Diseases

Suruchi Batra AND Laurie S. Conklin

SECTION X: Endocrine and Hematologic Pharmacology

54. Glucocorticoids

Nicolas C. Nicolaides, Tomoshige Kino, AND George P. Chrousos

55. Insulin and Diabetes

Eda Cengiz AND William V. Tamborlane

56. Growth Hormone

Jorge Mejia-Corletto AND Paul H. Saenger

57. Thyroid Hormones

Aditi Khokhar, Sheila Perez-Colon, Vatcharapan Umpaichitra, Vivian L. Chin, AND Delbert A. Fisher

58. Hematologic Agents

Sarah E. Kolnik, Kendell R. German, AND Sandra E. Juul

59. Clinical Pharmacology of Antineoplastic Drugs

Stacey L. Berg, Jennifer H. Foster, AND Lisa R. Bomgaars

SECTION XI: Nutritional Pharmacology, Pharmacotoxidromes, Adverse Drug Reactions, and Interactions

60. Nutrient Supplements

Mary Frances Picciano, Michelle K. McGuire, AND Paul M. Coates

61. Herbal Drugs in Children

Wayne R. Snodgrass AND Susan C. Smolinske

62. Pediatric Poisonings and Antidotes

Bram A. Dolcourt

63. Adverse Drug Reactions in Newborns and Children

Michael Rieder, Abdelbaset Elzagallaai, AND Bruce Carleton

64. Medication Errors in Children

L. M. Hanff

65. Drug Interactions in Newborns and Children

Kelly P. Shaw AND Shannon Manzi

Appendix A1: Neonatal Drug Formulary

Densley Francois, Mirjana Lulic-Botica, Thomas J. Duggan, and Jacob V. Aranda

Appendix A2: Pediatric Drug Formulary

Shannon F. Manzi

Index