Comparative Study on the Immunological Activity of a Series of Isoquinoline Alkaloids

Comparative Study on the Immunological Activity of a Series of Isoquinoline Alkaloids

Comparative Study on the Immunological Activity of a Series of Isoquinoline Alkaloids

Abstract

A series of eight isoquinoline alkaloids were isolated from Glauciurnflauurn or synthesized and subsequently their immunological activity was evaluated. The structure-effect relationships were evaluated in the following in uitro tests: complement activation, phagocytosis and antibody synthesis. Oxoglaucine caused significant inhibition of classical complement activity. Representatives with two phenolic hydroxyl groups decreased the phagocytic activity of peritoneal macrophages. All substances tested possessed suppressive effects on antibody synthesis against sheep red blood cells. Oxoglaucine was the most potent of the series.

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