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G Proteins, Cytoskeleton and Cancer
G Proteins, Cytoskeleton and Cancer
G Proteins, Cytoskeleton and Cancer
About this Book
This monograph is the very first book to comprehensively review the molecular links between G proteins, in particular the Ras/Rho family of GTPases, actin-cytoskeleton and tumorigenesis. More than 25 international experts in this rapidly developing field have contributed up-to-date chapters to this volume. This information will aid in understanding how actin-cytoskeleton is dramatically rearranged during malignant transformation. This information will aid in the design of novel drugs, potentially useful in the treament of cancer.
Table of Contents
Regulation of Actin Assembly and Disassembly
The Gelsolin Family of Actin Filament Severers and Cappers
Molecular Links Between Rho Family GTPases and Myosins
The Light-Chain-Linked Regulation of Muscle Myosin II
The Tumor-Suppressor 1(2)gl: A Myosin-Binding Protein Family
Focal Adhesion Kinase (FAK): Regulation of Its Tyr Phrosphorylation
Cytoskeletal Plaque Proteins: Their Role in the Regulation of Tumorigenesis
Regulation of a-Actinin and Vinculin Functions by PIP
Tumor Suppressive Function of Gelsolin
PIP2: A Protooncogenic Phospholipid
GTPase Regulators: GAPs, GDSs and GDIs
Oncogenic Ras Signaling Network
Structures of Ras and Its Complexes with Raf and GAP
Rho Family GTPases and Actin Cytoskeleton
Rho Effectors: Structure and Function
Rac/Cdc42 Effectors: ACK, PAK, MRCK, WASP, n-Chimerin, POR1, Etc
Flightless I
Mammalian IQGAPs
Farnesyltransferase Inhibitors: Agents for the Treatment of Human Cancer
SCH51344: An Inhibitor of RAS/RAC-Mediated Membrane Ruffling
Azatyrosine: Mechanism of Action
Histone Deacetylase Inhibitors: Possible Anti-Cancer Therapeutics
Bacterial Toxins Controlling Rho-GTPases
Antisense Oligonucleotides Against Ras
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