Hepatitis C Genotypes in Patients With Dual Hepatitis B and C Virus Infection

Hepatitis C Genotypes in Patients With Dual Hepatitis B and C Virus Infection

Hepatitis C Genotypes in Patients With Dual Hepatitis B and C Virus Infection

In patients with chronic hepatitis B and C virus
(HBV, HCV) infection, an inverse relationship in
the replicative activity of the two viruses has
been reported. In the present study the genotype
of HCV was evaluated in 34 consecutive cases
found with hepatitis B surface antigen (HBsAg)
and anti-HCV in the serum, in order to identify its
possible influence in determining the pattern of
HBV/HCV interaction. Nineteen patients were
HCV-RNA positive and could be genotyped: 8
were infected by HCV-1 (3 by HCV-la and 5 by
HCV-lb), 10 by HCV-2, and only 1 by HCV-3.
Among these, 3 were HBV-DNA positive, compared
to 10 of 15 HCV-RNA-negative patients
(P = 0.0031, and all 3 were coinfected with
Mean alanine aminotransferase (ALT) levels
were similar between patients infected with
HCV-1 and HCV-2. Among 7 patients with cirrhosis
5 were infected by HCV-2, while 6 of 12 of
those without cirrhosis had HCV-1 infection.
In conclusion, HBV replication was inhibited
more efficiently by HCV-1 than by HCV-2. Cirrhosis
was frequently found in patients with dual
HBV and HCV-2 infection.

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