Human memory T cells: generation, compartmentalization and homeostasis

Human memory T cells: generation, compartmentalization and homeostasis

Human memory T cells: generation, compartmentalization and homeostasis

Abstract

Memory T cells constitute the most abundant lymphocyte population in the body
for the majority of a person’s lifetime; however, our understanding of memory T cell
generation, function and maintenance mainly derives from mouse studies, which cannot
recapitulate the exposure to multiple pathogens that occurs over many decades in humans.
In this Review, we discuss studies focused on human memory T cells that reveal key properties
of these cells, including subset heterogeneity and diverse tissue residence in multiple mucosal
and lymphoid tissue sites. We also review how the function and the adaptability of human
memory T cells depend on spatial and temporal compartmentalization.

 

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