Immunosuppressive therapy (IT) with autologous hematopoietic stem cell transplantation (AHSCT) as a new treatment modality in multiple sclerosis (MS)

Immunosuppressive therapy (IT) with autologous hematopoietic stem cell transplantation (AHSCT) as a new treatment modality in multiple sclerosis (MS)

Immunosuppressive therapy (IT) with autologous hematopoietic stem cell transplantation (AHSCT) as a new treatment modality in multiple sclerosis (MS)

It is known that at stresses, the immune system and its interactions with
nervous and endocrine systems are disturbed (Leonard 2000). At present the
great role of brain function disturbances correction belongs to biologically
active peptides such as Selank (Sel) and Semax (Sem). The newly obtained
data show that Sel has immunomodulatory features (Myasoedov 2007). It has
been shown, that the application of Sem and Sel exerts positive therapeutic
effect in different neurological diseases. There are no data on cerebroprotective
effects of Sem and Sel in primates. The present work is devoted to the
study of Sem and Sel role in the compensation of mentally disturbed (mnestic,
cognitive) and vegetative functions in primates (Macaca mulatta). The
experiments were performed in two series. The first series was made with
freely moving animals, while the second one used monkeys placed into
primatological chair with multiparametrical registration of objective (EEG,
vegetative and motor) components of Higher Nervous Activity. It has been
established that in monkeys the compensatory effects of drugs are dose
dependent, being more effective with intranasal administration and having
differential effects at various types of neurosis. It has been shown that the
intranasal administration of Sel induces long lasting changes in monkeys’
disturbed behaviour during neurosis (loss of fear, disappearance of aggression,
the facilitation of handling reactions and communications relations).

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