Influenza: Propagation, Quantification, and Storage

Influenza: Propagation, Quantification, and Storage

Influenza: Propagation, Quantification, and Storage

ABSTRACT

Influenza viruses are negative-sense, single-stranded, enveloped RNA viruses belonging
to the family Orthomyxoviridae. Three types exist, influenza A, B, and C. All infect
humans, but only A and B are major human pathogens. Influenza type A viruses are
divided into subtypes based on genetic and antigenic differences in the two surface spike
proteins, hemagglutinin (HA) and neuraminidase (NA). The appropriate cell lines to
be used for isolation of influenza A or B viruses depend on the clinical information and
the host of origin. MDCK cells are the preferred cell line for isolation of human influenza
viruses from clinical specimens.
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