Jatrophone Inhibits Platelet Rich Plasma Aggregation from Man, Rat and Guinea-pig Induced by Different Agents

Jatrophone Inhibits Platelet Rich Plasma Aggregation from Man, Rat and Guinea-pig Induced by Different Agents

Jatrophone Inhibits Platelet Rich Plasma Aggregation from Man, Rat and Guinea-pig Induced by Different Agents

The effect of jatrophone (2.5-100 p~), a diterpene isolated from Jufropha ellipticu, upon the aggregation (platelet
rich plasma) induced by several agents in different animal species was examined. At the same range of inhibitory
concentrations (24.0-43.0 p~) previously shown to inhibit contractions triggered by different agents in isolated
muscle preparations, jatrophone markedly inhibited platelet aggregation. This effect was dose-dependent and it
was reversible for up to 30 min. It is concluded that this nonspecific effect could reflect an action of jatrophone
either at an intracellular step in the signal transduction process, which is common to different agonists, or at the
level of extracellular and/or intracellular Ca2’ mobilization.

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