Medicine

Local control of the immune response in the liver

Local control of the immune response in the liver

Local control of the immune response in the liver

Summary:

The physiological function of the liver – such as removal of
pathogens and antigens from the blood, protein synthesis and metabolism
– requires an immune response that is adapted to these tasks and is locally
regulated. Pathogenic microorganisms must be efficiently eliminated
while the large number of antigens derived from the gastrointestinal tract
must be tolerized. From experimental observations it is evident that the
liver favours the induction of tolerance rather than the induction of immunity.
The liver probably not only is involved in transplantation tolerance
but contributes as well to tolerance to orally ingested antigens (entering
the liver with portal-venous blood) and to containment of systemic
immune responses (antigen from the systemic circulation entering the
liver with arterial blood). This review summarizes the experimental data
that shed light on the molecular mechanisms and the cell populations of
the liver involved in local immune regulation in the liver.

 

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