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Nature Immunology November 2014
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November 2014 Volume 15 No 11
Cells of the immune system tailor their responses to microbe size. Branzk et al. demonstrate that neutrophils sense microbe size and selectively release neutrophil extracellular traps to control large pathogens (p 1017; News and Views by Mathew L. Wheeler and David M. Underhill, p 1000). The original image shows neutrophils responding to large fungal filaments (red) by releasing such traps that contain the antimicrobial protein myeloperoxidase (green) and decondensed DNA (blue).
Image by Nora Branzk and Venizelos Papayannopoulos. Artwork by Lewis Long.