Thymic Development and Selection of T Lymphocytes (Current Topics in Microbiology and Immunology)

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Book Description

The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.

  • Series: Current Topics in Microbiology and Immunology (Book 373)
  • Publisher: Springer; 2014 edition (November 19, 2013)
  • Language: English
  • ISBN-10: 3642402518
  • ISBN-13: 9783642402517

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