Ulva lactuca is PoorlyFermented but Alters Bacterial Metabolism in Rats Inoculated with Human Faecal Flora from Methane and Non-methane Producers

Ulva lactuca is PoorlyFermented but Alters Bacterial Metabolism in Rats Inoculated with Human Faecal Flora from Methane and Non-methane Producers

Ulva lactuca is PoorlyFermented but Alters Bacterial Metabolism in Rats Inoculated with Human Faecal Flora from Methane and Non-methane Producers

Abstract: In vivo fermentation of Ulva lactuca was studied in previously germfree rats inoculated with human ýora obtained from non-, low- and highmethane producers (groups NMP, LMP and HMP, respectively), in comparison
to germ-free rats. Rats were fed either a control diet or a diet containing 4% of
dried Ulva lactuca. Production of metabolites varied according to the ýora and
diet. Ulva lactuca induced a speciüc high production of methane in the HMP
group. With the three human ýora, Ulva diet induced a similar increase in caecal
pH. In the NMP and HMP groups, this increase was associated with a fall of
lactic acid caecal concentration. In the LMP group it was related to a decrease in
the concentration of short-chain fatty acids. Ulva lactuca appeared to be able to
regulate the b-glucuronidase and b-glucosidase activities, reducing the relatively
high levels observed in groups NMP and HMP and increasing the low levels
obtained in the LMP group. Results show that, although it was poorly fermented, Ulva induced signiücant eþects on the gut microýora metabolism. The
methanogenic status of the human donor appeared to be an important factor.

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